Job description
Hodgkin lymphoma is the most prevalent cancer in adolescents and young adults. Although current multi-agent chemotherapy treatments are effective, they often cause serious long-term side effects in survivors, including cardiovascular disease, infertility, and development of secondary cancers. This highlights a critical need for more specific treatments without these harmful side effects. While immune checkpoint inhibitors show promising results as monotherapy, with complete responses up to 30%, a better understanding of the tumor microenvironment is needed to be able to completely replace chemotherapy.
To improve our understanding of the Hodgkin lymphoma-immune cell interactome, we will take advantage of a unique in-house developed organoid system in which we can co-culture and experimentally manipulate Hodgkin lymphoma and immune cells and study their interactions. These experiments will be conducted by molecular biologists with whom you will closely interact. You will be involved in analyzing the large-scale single-cell multi-omics data (combined epigenetic and transcriptomic data) and spatial transcriptomics data to identify the most promising cell-to-cell interaction targets in Hodgkin lymphoma tissue that we will ultimately validate in patient material.