The European Research Institute for the Biology of Aging (ERIBA) is a research institute at the University Medical Centre Groningen (UMCG), in Groningen, the Netherlands. The mission of ERIBA is to better understand the molecular mechanisms that result in age-related decline and age-related diseases. We aim to develop novel strategies to prevent or combat age-related diseases and to provide evidence-based recommendations for healthy ageing. The research teams are working with different model systems and technology platforms and share their knowledge and expertise to accelerate discoveries. ERIBA is part of the central UMCG campus in the vibrant university city Groningen in the north of the Netherlands.
The Foijer lab at ERIBA is currently looking for a postdoctoral fellow who will study how chromosomal instability shapes cancer cell evolution.
Chromosomal instability (CIN) is the process through which cells gain and lose chromosomes and leads to cells with an abnormal DNA content, as state known as aneuploidy. As CIN causes genetic drift, it is a key contributor to the transformation process of healthy cells becoming cancer cells. CIN will therefore lead to differences between cells in a tumor, i.e. intratumor heterogeneity. However, while most cancers are indeed aneuploid, aneuploidy also significantly decreases cellular fitness of cells, presumably because most chromosome combinations are non-beneficial for (cancer) cells.