(Macro)autophagy is a conserved catabolic pathway that mediates lysosomal turnover of defective or excess intracellular structures, including protein complexes and organelles. The structures targeted to destruction are sequestered into double-membrane autophagosomes and delivered into lysosomes. In addition to eliminate cytoplasmic components in a random manner, autophagy can be highly selective by recognizing specific cargo via the so-called autophagy receptors. Types of selective autophagy are key in fine regulating a multitude of physiological functions, including cell differentiation and metabolism. Within this interdisciplinary collaborative project, we aim at providing a comprehensive mechanistic view about how selective autophagy is regulating metabolism during the adaptation to specific nutritional changes. This study will be initially performed in yeast Saccharomyces cerevisiae, before we will transfer key principles to cancer cells.
You are expected to conduct a research project, involving a combination of yeast genetics, cell biology, biochemistry (including proteomics and metabolomics), molecular biology, and live-cell imaging, embedded within the research group of Prof. Fulvio Reggiori.
The position is supported by the Sinergia program of the Swiss National Science Foundation (SNSF) and it is for four years, with a one-year trial period.